Anti-leukemia Activity of Methanolic Extracts of Lantana camara

JOURNAL:
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Volume :1
Issue :5
September 2009 - October 2009
Page No: 
274-279
Authors: 
Badakhshan Mahdi Pour [1]*, Sreenivasan Sasidharan [1], Rameshwar Naidu Jegathambigai [1] and Ramanathan Surash [2]
Address: 
[1]Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia.
[2] Centre for Drug Research, University Science of Malaysia, 11800 Minden, Pulau Pinang. Malaysia.

ABSTRACT

Anticancer effect of Lantana camara’s root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 ± 53.08 μg/ml; leaf, 394.41 ± 99.73 μg/ml; p > 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 ± 3.60 μg/ml; p < 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara’s root and leaf extracts might be subjects for
further fractionation and identification to find new anticancer agents.

Keywords: 
Anticancer, Cell Culture, Jurkat Cell Line, Lantana camara, MTT Assay.

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